India earned a penalty corner early in the second quarter and tried a variation and Vandana was there to deflect the ball home off a rebound to make it 2-1 for India.
The Punjab athlete, Kamalpreet has been in impressive form this year as she breached the 65m mark twice recently.
Despite this loss, the 25-year-old Panghal remains one of best-performing Indian boxers in recent times.
Das shot twice in the red-circle (8-8) in his last two arrows of the opening set to lose by two points (25-27).
COVID-19 infections totalled 3,300 in Tokyo on Friday, after hitting a record 3,865 a day earlier.
Sindhu will next face the winner of the other quarterfinal between Thailand's Ratchanok Inthanon and Chinese Taipei's Tai Tzu Ying.
India will now need to win their final Pool A match against South Africa on Saturday and hope Ireland loses to Great Britain to seal their quarterfinal berth.
The 23-year-old Assam boxer will square off against reigning world champion Busenaz Surmeneli of Turkey, who hammered Anna Lysenko in her quarterfinal bout.
For the three-time Olympian Deepika, this was her first win from three matches against the 2017 world champion as she became the first Indian to make the last-eight in an individual event of the Olympics.
A week on, and India's performance in the Tokyo Olympics has been rather dismal with just a single silver medal to her name all thanks to weightlifter Mirabai Chanu.
Indian rowers, Arjun Lal Jat and Arvind Singh, ended 11th over in the men's lightweight double sculls competition at the Tokyo Olympics on Thursday.
The 38-year-old, who is a multiple-time Asian champion and a bronze-winner from the 2012 London olympics, lost 2-3 to the Colombian, giving it her all in what would now be her final Olympic bout.
Earlier on Thursday, men's pole vaulter German Chiaraviglio of Argentina had also been ruled out of the Olympics due to a positive COVID-19 result.
Indian shooters Manu Bhaker and Rahi Sarnobat were placed 5th and 25th respectively in the women's 25m pistol qualification (precision) at the Tokyo Olympics
Boxer Satish Kumar is through to the QFs of the +91kg event after beating Ricardo Brown of Jamaica.
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