The AY.4.2 belongs to the same family of mutations that define the B.1.617.2, or Delta variant of the Novel Coronavirus that was first identified in India in October 2021.
WHO has designated the MU strain of coronavirus as a 'variant of interest'.
The variant has evolved from C.1, one of the lineages that dominated the first wave of SARS-CoV-2 infections in South Africa and was last detected in January 2021.
Among the coronavirus family, one viral sub-group relies on the ACE2 molecule -- a protein found on the surface of many cell types -- to enter human cells. Neutralising antibodies are able to prevent the viral spike protein from binding with the ACE2 molecules in human cells.
Variants are continuing their progression, as the Alpha variant was seen in 180 countries while the Delta variant was reported from 13 new countries.
The Delta Covid-19 variant has now been detected in 96 countries, 11 more than last week, the World Health Organization (WHO) said in its latest update.
New York, June 26 (IANS) As SARS-CoV-2, the virus causing Covid-19, evolves it tends to mutate and bring new variants as well as cause changes to the spike protein -- a fact that can render the current vaccines targeting the protein ineffective. Researchers from the Boston Children's Hospital, have found new properties in the spike protein of the Alpha, first identified in the UK and Beta, first identified in South Africa variants. The changes to the 'spike' protein explains faster spread of Alpha, and how the Beta variant evades immune responses, suggesting the need for a booster with an updated vaccine. "The mutations make antibodies stimulated by the current vaccine less effective," said Bing Chen, in the division of Molecular Medicine at Boston Children's. "The Beta variant is somewhat resistant to the current vaccines, and we think a booster with the new genetic sequence can be beneficial for protecting against this variant," Chen added. Spike proteins, on the surface of SARS CoV-2, are what enable the virus to attach to and enter our cells, and all current vaccines are directed against them. The new study, published in Science, used cryo-electron microscopy (cryo-EM) to compare the spike protein from the original virus with that of the Alpha and Beta variants. The structural findings indicate that mutations in the Beta variant (also known as B1351) change the shape of the spike surface at certain locations. As a result, neutralising antibodies induced by current vaccines are less able to bind to the Beta virus, which may allow it to evade the immune system even when people are vaccinated. However, the study also found that mutations in the Beta variant make the spike less effective in binding to ACE2 -- suggesting that this variant is less transmissible than the Alpha variant. As for the Alpha variant (B117), the study confirms that a genetic change in the spike (a single amino acid substitution) helps the virus bind better to ACE2 receptors, making it more infectious. However, testing indicates that antibodies elicited by existing vaccines can still neutralise this variant.
In the context of public discourse regarding detection of new variants, NITI Aayog Member (Health) V.K. Paul has reminded that the newly detected 'Delta Plus' variant is not yet classified as a Variant of Concern (VOC).
China, Japan, the Philippines and Thailand may turn into "hotspots" favourable for bats that carry coronaviruses, and conditions in these places could become ripe for the disease to jump from bats to humans, finds a new study.
The B.1.617.1 and B.1.617.2 variants of the COVID-19, first identified in India, have been named as 'Kappa' and 'Delta' respectively, the World Health Organisation (WHO) announced on Monday as it named various variants of the coronavirus using Greek alphabets.
Delhi Chief Minister Arvind Kejriwal's claim on 'new variant of coronavirus' in Singapore which could reach India sparked off a diplomatic row.
New Delhi: The genetic diagnostic laboratories in India have detected over 24,000 mutations in the strains of SARS-CoV-2 in the last one year, top officials told IANS on Tuesday. The officials added that the mutations have been detected in around 7,000 variants of the novel coronavirus which are under circulation in the country. “We have […]
New Delhi: Variants of the novel coronavirus carrying two specific mutations in their spike protein may evade antibodies and make vaccines less effective, according to eminent virologist Shahid Jameel, who says the need of the hour is to improve surveillance for “homegrown” lineages of the virus. Jameel, Director of the Trivedi School of Biosciences at […]