Gilani initially refused to comment when journalists asked him about Clinton`s remarks on the sidelines of an official function here this afternoon.
"That`s her point of view. You can`t impose restrictions on anyone`s thoughts," he said.
When reporters kept pressing him on the issue, Gilani remarked: "Pakistan doesn`t want any chaudhry (headman)".
The word "chaudhry" is usually used in both India and Pakistan to refer to a local leader or influential person.
During her recent visit to India, Clinton had told a gathering in Chennai that the time had come for India to "seize the emerging opportunities of the 21st century" and "to lead".
Clinton`s remarks created a flutter in Pakistan as they came at a time when relations between Washington and Islamabad have plunged to a new low in the wake of a series of incidents, including the covert American raid that killed Osama bin Laden in the garrison city of Abbottabad on May 2.