"Some of the senior staff who spoke to her about half an hour ago say that she's sounding terrific, upbeat, raring to go. She's looking forward to getting back to the office," State Department spokesperson Victoria Nuland told reporters.
A day after her discharge from hospital, where she was admitted over the weekend due to a blood clot in her head, Clinton was resting at home.
Clinton, 65, has not been seen in public since December 7, after a blood clot was discovered in a vein between her skull and the brain.
She was admitted to a New York hospital on Sunday after she fainted and fell down while recovering from a stomach infection.
"She is very much planning to do so next week, and we'll have further precise details about that as she continues to make progress," she said.
The State Department has said that Clinton is keeping up with her work by talking to her staff and receiving memos.
Yesterday, Clinton dialled into meeting of the Foreign Policy Advisory Board.
The "conversation focused on a number of long-term issues, including energy and climate policy, expeditionary diplomacy, and foreign policy priorities for President Obama's second term," Nuland said.
"The Secretary closed by wishing the board a Happy New year, noting she's planning on returning to the office next week," according to a statement released later.
Responding to reporter's questions, Nuland said the State Department is in talks with the Congressional leaders for her testimony on Benghazi incident that killed three US nationals including the US Ambassador to Libya.