Wen held talks with Gilani at the Great Hall of the People in Beijing today.
The two leaders reaffirmed two countries will maintain all-weather friendship, Chinese state run Xinhua reported.
Before the close-door talks, Wen held a welcoming ceremony for Gilani, who arrived in Shanghai yesterday for a four-day visit to China.
Chinese Foreign Ministry spokeswoman Jiang Yu said earlier that during Gilani`s visit, the two sides will exchange views on deepening bilateral relations, promoting pragmatic cooperation in a wide range of areas and other international and regional issues of common concern.
Pakistan`s Ambassador to China Masood Khan said the two countries will sign a number of agreements in the fields of economy, technology and defence during Gilani`s visit.
The Pakistan Prime Minister was scheduled to meet Chinese President Hu Jintao later.
Gilani`s visit to kick off events to mark 60th year of establishment of diplomatic relations between the two countries, has been overshadowed by Pak-US tensions over the killing of Osama bin Laden.
Ahead of Gilani`s visit, China announced "unswerving" support to Pakistan`s counter terrorism efforts and asked US to strengthen anti-terror cooperation with Pak by providing more aid.
"Indeed Pakistan is the victim of terrorism."
Pakistan has made very important contribution to international counter terrorism cooperation as well as great sacrifices," Jiang had said yesterday as Gilani arrived Shanghai for a four-day visit.
Gilani arrived in Beijing today after attending an international cultural conference in Suzhou city in eastern China, where he said, Pakistan and China being close friends and good neighbours enjoyed the all-weather friendship which was deeply rooted in the hearts and minds of their peoples.
Pakistan "admired the accomplishments of the great Chinese nation," he said, adding that the world was witnessing today a renaissance of the ancient and glorious Chinese civilisation.
"I have no doubt that Chinese sagacity and thought will have a profoundly beneficial impact for the mankind, as a whole. We are happy to see China shape the 21st Century world," Gilani said.