The accident happened when the car, a Chevrolet Camaro, hit the tractor-trailer, the Oklahoma Highway Patrol spokesman Capt Chris West said.
The car slid underneath the semi, went down an embankment and burst into flames. All five people in the car were ejected and killed at the scene.
The five have been identified as Jaswanth Reddy Subbayyagari, Phanindra Gade, Anurag Anthati, Srinivas Ravi and Venkat, the Telugu Association of North America (TANA) said quoting friend of those who died in the accident. Among these people, only Venkat was married.
The truck driver was not hurt. Police said none of them were wearing seatbelts.
TANA president, Prasad Thotakura, said the organization with working with the police and local community to inform the families of the deceased, and making necessary arrangements to send the bodies to India.