Apart from Tendulkar and Yuvraj, there is also a question mark over Virender Sehwag`s fitness alongwith a host of other players who suffered injuries during India`s disastrous tour of England recently.
While the selectors, who meet here on Thursday, may find the replacements in the batting department, the bowling unit is of more concern as three premier speedsters in Zaheer Khan, Ishant Sharma and Munaf Patel are out of contention.
The first two games of the five-match ODI series against England will be played in Hyderabad on October 14 and New Delhi on October 17. The other matches will be held in Mohali (Oct 20), Mumbai (Oct 23) and Kolkata (Oct 25).
Tendulkar, who was ruled out of the last ODI series in England due to a toe injury, is yet to play a match in the Champions League Twenty20 and indications are that he may miss out the first two matches.
Sehwag, who had hearing problems as well as recuperating from shoulder surgery, may also have to sit out of the first two one-dayers though there is still no clear indication on his fitness status.
The good news is that Gautam Gambhir has recovered fully and he has now played two matches for KKR in the ongoing Champions League and should be back in the team.
Similarly Harbhajan Singh`s name would also come up for consideration as the stand-in captain of Mumbai Indians appeared to have regained full fitness from the stomach injury as he has contributed with both bat and ball.