Apart from Tendulkar, who is nursing a toe injury, Mumbai will also be without Rohit Sharma, Suryakumar Yadav, Ali Murtaza, Munaf Patel and Dhawal Kulkarni.
To be led by Harbhajan Singh in Tendulkar`s absence, Mumbai have been allowed five foreign players instead of the stipulated four due to the injury crisis in the team.
The injured have been replaced by Andrew Symonds, Dilhara Fernando, R Sathish, Sarul Kanwar and Abu Nechim.
They face an unbeaten-at-home Chennai Super Kings, who are not just defending champions but also the winners of this season`s IPL title.
The only key player that the Mahendra Singh Dhoni-led team will miss is New Zealand pacer Tim Southee.
Chennai will enjoy the home advantage for almost the entire tournament as they are playing all their group matches here while the semifinals and the final are also scheduled in the city only.
In all counts, Mumbai will find it tough to contain Chennai`s batting line-up which features, apart from Dhoni, some steady customers such as Michael Hussey and IPL find S Anirudha who can change the pace of the game.
Chennai`s bowling too looks solid with pacers such as Doug Bollinger and Albie Morkel. The spin department features the sprightly R Ashwin and Suraj Randiv.