blood test – Odisha Television Ltd. https://odishatv.in OdishaTV - OTV Fri, 03 Jul 2020 10:42:43 +0000 en-US hourly 1 https://odishatv.in/wp-content/uploads/2017/05/otv_small_logo.png blood test – Odisha Television Ltd. https://odishatv.in 32 32 Blood Tests Can Predict Risk Of Severe Liver Disease https://odishatv.in/health/blood-tests-can-predict-risk-of-severe-liver-disease-460213 Fri, 03 Jul 2020 10:42:43 +0000 https://odishatv.in/?p=460213

London: Researchers have found that repeated measurements of the biomarker FIB-4 in human blood every few years can predict the risk of developing severe liver disease. According to a study published in the Journal of Hepatology, the risk of liver cirrhosis increases if the levels of this biomarker rise between two testing occasions. Fat accumulation […]

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London: Researchers have found that repeated measurements of the biomarker FIB-4 in human blood every few years can predict the risk of developing severe liver disease.

According to a study published in the Journal of Hepatology, the risk of liver cirrhosis increases if the levels of this biomarker rise between two testing occasions.

Fat accumulation in the liver is common and is often seen in people with obesity or diabetes. In the worst case, fatty liver can lead to cirrhosis or liver cancer. It is unusual for this to occur but in those affected, symptoms often only occur at a late stage when there is no available treatment.”

It is difficult to predict the risk of cirrhosis, although you can get some guidance in using regular blood tests that measure liver damage,” said study lead author Hannes Hagstrom from Karolinska Institutet in Sweden.

“Therefore, we wanted to investigate whether what is known as the FIB-4 score can increase the accuracy of the identification of people at high risk, in particular with information from repeated measurements,” Hagstrom added.

The new study shows that repeated sampling and measurements of the FIB-4 score, rather than measuring FIB-4 on one sole occasion, can increase the prediction of future liver cirrhosis.

The researchers used the ‘AMORIS’ cohort that contains laboratory test data in a very large population, surveyed between 1985 and 1996.

More than 40,000 people had contributed to the blood test data for FIB-4 on several sampling occasions. They were followed in national registers to identify those who developed cirrhosis after up to 27 years.

The main finding was that the risk increases in people where the FIB-4 score rises between two testing occasions and decreases when it falls.

In this way, almost half of those who were later affected by cirrhosis could be identified.

One problem, however, was that the accuracy was relatively low, with a risk of false-positive tests, the researchers said.

The study also established that it took a long time to develop cirrhosis, and that it may be enough to recalculate the FIB-4 score at intervals of several years.

“We show that this biomarker is useful for identifying people in primary care with an increased risk of cirrhosis who may need to be more carefully investigated and to exclude people who do not need this,” Hagstrom said.

“But the method needs to be further developed to reduce the risk of false-positive findings, which can lead to unnecessary examinations in healthy people,” the study author noted.

 

(IANS)

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Blood Test Can Identify People At Risk Of Night-Time High BP https://odishatv.in/health/blood-test-can-identify-people-at-risk-of-night-time-high-bp-420140 Sat, 07 Dec 2019 15:50:22 +0000 https://odishatv.in/?p=420140

New York: Researchers have found that a simple blood test can help identify people with obstructive sleep apnea (OSA) who are at higher risk of cardiovascular problems because of a phenomenon called “reverse dipping” that causes blood pressure to rise rather than lower during sleep. Most people experience lower blood pressure at night. The new […]

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New York: Researchers have found that a simple blood test can help identify people with obstructive sleep apnea (OSA) who are at higher risk of cardiovascular problems because of a phenomenon called “reverse dipping” that causes blood pressure to rise rather than lower during sleep.

Most people experience lower blood pressure at night. The new study, published in the European Respiratory Journal suggests a potential cause for reverse dipping that may help patients with sleep apnea get the help they need before cardiovascular disease develops.

“We can now identify those with OSA at the highest risk of cardiovascular problems in order to prevent them from developing additional complications,” said David Gozal from the University of Missouri School of Medicine in the US.

“We can treat those patients more aggressively to ensure they adhere to therapy and use their continuous positive airway pressure device (CPAP) properly,” Gozal said.

The researchers studied 46 patients diagnosed with OSA. They ranged in age from 18 to 70. Fifteen participants were identified to have a rise in blood pressure during sleep, while the remaining 31 participants had blood pressure readings that either remained the same or declined at night.

The researchers collected a blood sample from each participant to study the messages cells produce and send to each other through microscopic packages called exosomes.

“We found that the cell messages coming from participants with night-time elevated blood pressure were different than those transmitted in subjects with normal blood pressure,” Gozal said.

“The altered messages caused the cells that line the blood vessels to become dysfunctional. Those disturbed vessels allowed inflammatory cells to enter the vessels’ walls, causing hardening of those vessels and leading to cardiovascular disease.”

Gozal said the cell message discovery will help clinicians personalise treatment for each patient diagnosed with OSA.

A simple blood test administered at the beginning of a sleep study could indicate each patient’s cardiovascular risk, said the study.

(IANS)

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Blood Test To Detect Breast Cancer Signs 5 Years Sooner https://odishatv.in/health/blood-test-to-detect-breast-cancer-signs-5-years-sooner-412839 Sun, 03 Nov 2019 07:29:12 +0000 https://odishatv.in/?p=412839

London: Researchers have found that a simple blood test can detect breast cancer up to five years before there are any clinical signs of it. The blood test identifies the body’s immune response to substances produced by tumour cells, according to the research presented at the 2019 NCRI (National Cancer Research Institute) Cancer Conference in […]

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London: Researchers have found that a simple blood test can detect breast cancer up to five years before there are any clinical signs of it.

The blood test identifies the body’s immune response to substances produced by tumour cells, according to the research presented at the 2019 NCRI (National Cancer Research Institute) Cancer Conference in Glasgow, UK, on Sunday.

“We need to develop and further validate this test,” said Daniyah Alfattani from the University of Nottingham in Britain.

“However, these results are encouraging and indicate that it’s possible to detect a signal for early breast cancer. Once we have improved the accuracy of the test, then it opens the possibility of using a simple blood test to improve early detection of the disease,” she said.

Cancer cells produce proteins called antigens that trigger the body to make antibodies against them — auto-antibodies.

The researchers have found that these tumour-associated antigens (TAAs) are good indicators of cancer, and now they have developed panels of tumour-associated antigens that are known already to be associated with breast cancer to detect whether or not there are auto-antibodies against them in blood samples taken from patients.

In a pilot study, the researchers took blood samples from 90 breast cancer patients at the time they were diagnosed with breast cancer and matched them with samples taken from 90 patients without breast cancer (the control group).

They used screening technology (protein microarray) that allowed them to screen the blood samples rapidly for the presence of auto-antibodies against 40 tumour-associated antigens associated with breast cancer, and also 27 tumour-associated antigens that were not known to be linked with the disease.

“The results of our study showed that breast cancer does induce autoantibodies against panels of specific tumour-associated antigens. We were able to detect cancer with reasonable accuracy by identifying these auto-antibodies in the blood,” Alfattani said while presenting the research.

The researchers identified three panels of tumour-associated antigens against which to test for autoantibodies. The accuracy of the test improved in the panels that contained more tumour-associated antigens.

The panel of five tumour-associated antigens correctly detected breast cancer in 29 per cent of the samples from the cancer patients and correctly identified 84 per cent of the control samples as being cancer-free.

The panel of seven tumour-associated antigens correctly identified cancer in 35 per cent of cancer samples and no cancer in 79 per cent of control samples. The panel of nine antigens correctly identified cancer in 37 per cent of cancer samples and no cancer in 79 per cent of the controls.

The researchers are now testing samples from 800 patients against a panel of nine tumour-associated antigens, and they expect the accuracy of the test to improve with these larger numbers.

“A blood test for early breast cancer detection would be cost-effective, which would be of particular value in low and middle income countries. It would also be an easier screening method to implement compared to current methods, such as mammography,” said Alfattani.

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New Blood Test May Detect 20 Types Of Cancers https://odishatv.in/health/new-blood-test-may-detect-20-types-of-cancers-404852 Sat, 28 Sep 2019 10:25:03 +0000 https://odishatv.in/?p=404852

New York: A new blood test has shown ability to screen numerous types of cancer with a high degree of accuracy. A trial of the test showed it detected and localized more than 20 types of cancers. The test, developed by biotechnology company Grail Inc uses next-generation sequencing technology to probe DNA for tiny chemical […]

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New York: A new blood test has shown ability to screen numerous types of cancer with a high degree of accuracy. A trial of the test showed it detected and localized more than 20 types of cancers.

The test, developed by biotechnology company Grail Inc uses next-generation sequencing technology to probe DNA for tiny chemical tags (methylation) that influence whether genes are active or inactive.

When applied to nearly 3,600 blood samples — some from patients with cancer and some from people who had not been diagnosed with cancer at the time of the blood draw — the test successfully picked up a cancer signal from the cancer patient samples, and correctly identified the tissue from where the cancer began (the tissue of origin),” said investigators from Boston-based Dana-Farber Cancer Institute.

The test’s specificity – its ability to return a positive result only when cancer is actually present – was high, as was its ability to pinpoint the organ or tissue of origin, they found.

The new test looks for DNA, which cancer cells shed into the bloodstream when they die.

In contrast to “liquid biopsies,” which detect genetic mutations or other cancer-related alterations in DNA, the technology focuses on modifications to DNA known as methyl groups.

Methyl groups are chemical units that can be attached to DNA, in a process called methylation, to control which genes are “on” and which are “off.”

Abnormal patterns of methylation turn out to be, in many cases, more indicative of cancer – and cancer type — than mutations are.

“Our previous work indicated that methylation-based assays outperform traditional DNA-sequencing approaches to detecting multiple forms of cancer in blood samples,” said the study’s lead author Geoffrey Oxnard from Dana-Farber.

“The results of the new study demonstrate that such assays are a feasible way of screening people for cancer,” Oxnard added.

Detecting even a modest percent of common cancers early could translate into many patients who may be able to receive more effective treatment if the test were in wide use, the study said.

Dana-Farber Cancer Institute investigators presented the results of the trial during a session at the European Society for Medical Oncology (ESMO) 2019 Congress in Barcelona, Spain, on September 28.

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20 types of cancers, blood test, how to detect cancer by blood test, types of cancer 2019-09-28 15:55:03 https://odishatv.in/wp-content/uploads/2019/06/cancer.jpg
Blood test to spot Alzheimer’s before symptoms occur https://odishatv.in/health/blood-test-to-spot-alzheimers-before-symptoms-occur-368401 Sat, 04 May 2019 12:54:39 +0000 https://odishatv.in/?p=368401

London: Researchers have developed a new test that could help doctors detect Alzheimer’s disease eight years before the first symptoms occur. Using current techniques, Alzheimer’s disease, the most frequent cause of dementia, can only be detected once the typical plaques have formed in the brain. At this point, therapy seems no longer possible. However, the […]

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London: Researchers have developed a new test that could help doctors detect Alzheimer’s disease eight years before the first symptoms occur.

Using current techniques, Alzheimer’s disease, the most frequent cause of dementia, can only be detected once the typical plaques have formed in the brain.

At this point, therapy seems no longer possible. However, the first changes caused by Alzheimer’s take place on the protein level up to 20 years sooner.

“Once amyloid plaques have formed, it seems that the disease can no longer be treated,” said study co-author Andreas Nabers from Ruhr-University Bochum in Germany.

In Alzheimer’s patients, the amyloid beta protein folds incorrectly due to pathological changes long before the first symptoms occur.

A team of researchers headed by Klaus Gerwert from Ruhr-University Bochum successfully diagnosed this misfolding using a simple blood test. As a result, the disease could be detected approximately eight years before the first clinical symptoms occur.

But experiments showed that the test was not suitable for clinical applications as the test provided false positive diagnoses for nine per cent of the study participants.

In order to increase the number of correctly identified Alzheimer’s cases, the researchers have now introduced the two-tier diagnostic method.

To this end, they use the original blood test to identify high-risk individuals. Subsequently, they add a dementia-specific biomarker, namely tau protein, to run further tests with those test participants whose Alzheimer’s diagnosis was positive in the first step.

If both biomarkers show a positive result, there is a high likelihood of Alzheimer’s disease, said the study published in the journal Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring.

“Through the combination of both analyses, 87 of 100 Alzheimer’s patients were correctly identified in our study,” Gerwert said.

“Now, new clinical studies with test participants in very early stages of the disease can be launched,” Gerwert added.

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Novel blood test for pain may help combat opioid epidemic https://odishatv.in/health/novel-blood-test-for-pain-may-help-combat-opioid-epidemic-352941 Fri, 15 Feb 2019 05:21:04 +0000 https://odishatv.in/?p=352941

New York: A one-of-its-kind blood test to measure pain in patients could open the door to precision medicine and help stem the tide of the opioid crisis, say researchers. Until now, to assess pain – a subjective sensation – doctors had to rely on patients self-reporting or the clinical symptoms. But the novel blood test […]

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New York: A one-of-its-kind blood test to measure pain in patients could open the door to precision medicine and help stem the tide of the opioid crisis, say researchers.

Until now, to assess pain – a subjective sensation – doctors had to rely on patients self-reporting or the clinical symptoms.

But the novel blood test can help objectively determine how severe a patient’s pain is, allowing physicians far more accuracy in treating it.

“We have developed a prototype for a blood test that can objectively tell doctors if the patient is in pain, and how severe that pain is,” Alexander Niculescu, Professor of Psychiatry at Indiana University, said.

With an opioid epidemic raging, Niculescu said never has there been a more important time to administer drugs to patients responsibly.

“The opioid epidemic occurred because addictive medications were overprescribed as there was no objective to measure whether someone was in pain, or how severe their pain was,” Niculescu said, in a paper detailed in the journal Molecular Psychiatry.

In addition to providing an objective measure of pain, the blood test helps physicians match the biomarkers in the patient’s blood with potential treatment options.

The researchers utilise a prescription database to match the pain biomarkers with profiles of drugs and natural compounds catalogued in the database.

“The biomarker is like a fingerprint, and we match it against this database and see which compound would normalise the signature,” Niculescu said.

“We have been able to match biomarkers with existing medications, or natural compounds, which would reduce or eliminate the need to use the opioids.”

Moreover, the team discovered biomarkers that can also help predict when someone might experience pain in the future – helping to determine if a patient is exhibiting chronic, long-term pain, which might result in future emergency room visits.

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Israel discovers blood test to match treatment to lung cancer https://odishatv.in/health/israel-discovers-blood-test-to-match-treatment-to-lung-cancer-328824 Tue, 23 Oct 2018 05:30:53 +0000 https://odishatv.in/?p=328824

Jerusalem: Israeli researchers have discovered a method for matching precise treatment to lung cancer patients through simple blood tests, Hebrew-language website “Ynet” reported on Monday. The study, conducted by the oncology department at Soroka Hospital in southern Israel, examined the contribution of the use of “Guardant360” non-invasive liquid biopsy to match accurate treatment for patients […]

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Jerusalem: Israeli researchers have discovered a method for matching precise treatment to lung cancer patients through simple blood tests, Hebrew-language website “Ynet” reported on Monday.

The study, conducted by the oncology department at Soroka Hospital in southern Israel, examined the contribution of the use of “Guardant360” non-invasive liquid biopsy to match accurate treatment for patients with metastases.

Guardant360 test detects DNA segments in the patient’s blood, originated from the cancerous tumor or its metastasis.

After examining 116 advanced stage non-small-cell lung carcinoma cancer patients, the study concluded that 65 percent of the patients had a genetic modification that could be treated with drugs approved by the US Food and Drug Administration.

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New blood test to screen for secondary heart attack https://odishatv.in/health/new-blood-test-to-screen-for-secondary-heart-attack-320280 Fri, 07 Sep 2018 11:04:19 +0000 https://odishatv.in/?p=320280

Sydney: Australian scientists are developing a simple blood test that quickly and easily detects whether a person is at risk of a secondary heart attack. The simple blood test, similar to the process and cost of having a cholesterol test, could be operated out of hospital pathology laboratories that already contain the necessary equipment. It […]

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Sydney: Australian scientists are developing a simple blood test that quickly and easily detects whether a person is at risk of a secondary heart attack.

The simple blood test, similar to the process and cost of having a cholesterol test, could be operated out of hospital pathology laboratories that already contain the necessary equipment.

It will reclassify a patient’s risk of heart attack and stroke and will better identify who, within the “intermediate” risk category, are in fact at higher risk, and help guide physicians in the appropriate treatment of patients.

The team led by Professor Peter Meikle at the Baker Heart and Diabetes Institute in Melbourne identified plasma lipid biomarkers (fats in the blood) that improve upon traditional risk factors in predicting heart disease and stroke.

“We hope to identify those individuals who are at greatest risk of a second heart attack so that they can be closely monitored and treated accordingly,” Meikle said.

“While there are thousands of lipids in the blood, our challenge is to identify which ones best predict disease outcomes,” he noted.

The test, published in the journal JCI Insight, will use upto ten lipid markers to better diagnose heart disease.

“Once the protocols for a diagnostic heart disease blood test are in place, it will be possible for additional markers for the test to also be used in predicting diabetes and potentially Alzheimer’s disease as well,” Meikle said.

It was developed after a study looked at 10,000 samples to find the biomarkers that will determine whether a person is at risk of having another heart attack.

According to Meikle, the revolutionary test is proposed to be trialled in Australia over the next 2-3 years as part of a broader personalised precision health programme currently under development.

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New blood test to predict TB onset two years in advance https://odishatv.in/health/new-blood-test-to-predict-tb-onset-two-years-in-advance-286514 Fri, 06 Apr 2018 09:15:24 +0000 http://odishatv.in/?p=286514

Johannesburg: Researchers have developed a new blood test that can more accurately predict the development of tuberculosis (TB) up to two years before its onset in high-risk patients. The new test predicts TB particularly in people living with persons having active TB — a condition when the immune system is unable to stop the bacteria […]

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Johannesburg: Researchers have developed a new blood test that can more accurately predict the development of tuberculosis (TB) up to two years before its onset in high-risk patients.

The new test predicts TB particularly in people living with persons having active TB — a condition when the immune system is unable to stop the bacteria from growing.

The blood test works by measuring the expression levels of four genes signature in the blood known as “RISK4” — a combination of four genes associated with inflammatory responses.

“We found that this prediction (up to two years before the onset of the disease) is possible through measurements of a combination of a four-gene signature in the blood,” said lead author Gerhard Walzl, Professor at the Stellenbosch University in South Africa.

While “an individual component of this signature may not be sufficient to deliver an accurate diagnosis of prediction, but a combination of these markers improves its accuracy,” Walzl added.

The new test also predicts the development of TB without putting large numbers of lower-risk people through unnecessary preventative treatment.

The findings were published in the American Journal of Respiratory and Critical Care Medicine.

Focusing on people who lived with someone with active TB, the research team enrolled 4,466 HIV-negative participants and took their blood samples.

“We are hoping that primary health clinics will be able to use such a test and the reagents would then be readily available in that format, similar to the tests that are currently used to diagnose TB,” Walzl noted.

Tuberculosis, caused by infection with Myobacterium tuberculosis (M.tb), is the world’s leading cause of death brought on by a single pathogen.

More than 10 million new cases of TB are diagnosed each year, and almost two million people die from the disease. Globally, 1.7 billion people are estimated to be infected with M.tb.

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Ultrasound, blood test together may boost liver cancer detection https://odishatv.in/health/ultrasound-blood-test-together-may-boost-liver-cancer-detection-275756 Sun, 11 Feb 2018 18:51:38 +0000 http://odishatv.in/?p=275756

New York: Earlier detection is important to improving survival of patients with liver cancer, and combining an ultrasound imaging with a blood test can help achieve that, say researchers, including one of Indian-origin. Using ultrasound and a blood test for high alpha fetoprotein (AFP) levels together improves detection of early-stage liver cancer significantly, said the […]

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New York: Earlier detection is important to improving survival of patients with liver cancer, and combining an ultrasound imaging with a blood test can help achieve that, say researchers, including one of Indian-origin.

Using ultrasound and a blood test for high alpha fetoprotein (AFP) levels together improves detection of early-stage liver cancer significantly, said the study published in the journal Gastroenterology.

AFP is a plasma protein that is produced in abundance by the liver cells in the foetus. In adults, AFP levels are normally low, but liver cancer can cause AFP levels to rise.

“Liver cancer screening in patients with chronic liver disease has traditionally been performed using an abdominal ultrasound. While ultrasound is readily available and noninvasive, it misses many cancers when they are small,” said Amit Singal, associate professor at the University of Texas Southwestern Medical Centre.

Risk factors for liver cancer — also known as hepatocellular carcinoma (HCC) — include hepatitis C infection, chronic heavy alcohol consumption, and nonalcoholic fatty liver disease related to diabetes and obesity.

Symptoms can include upper abdominal pain or swelling, loss of weight or appetite, white chalky stools, and general fatigue, the researchers said.

“Our study found that adding the blood biomarker alpha fetoprotein increased detection of early-stage hepatocellular carcinoma from 45 per cent with ultrasound alone to 63 per cent using the two tests in combination,” Singal said.

Liver cancer screening guidelines for patients with cirrhosis vary, with some guidelines calling for just imaging and other guidelines calling for both imaging and AFP measurement.

“Our results support a change in clinical practice and the routine use of ultrasound and biomarkers together for liver cancer screening,” Singal said.

The results were based on a meta-analysis of 32 previous studies. Meta-analysis refers to a technique of combining the results of multiple scientific studies.

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Blood test plus ultrasound may boost liver cancer detection https://odishatv.in/science/blood-test-plus-ultrasound-may-boost-liver-cancer-detection-275659 Sun, 11 Feb 2018 09:28:36 +0000 http://odishatv.in/?p=275659

New York: Earlier detection is important to improving survival of patients with liver cancer, and combining an ultrasound imaging with a blood test can help achieve that, say researchers, including one of Indian-origin. Using ultrasound and a blood test for high alpha fetoprotein (AFP) levels together improves detection of early-stage liver cancer significantly, said the […]

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New York: Earlier detection is important to improving survival of patients with liver cancer, and combining an ultrasound imaging with a blood test can help achieve that, say researchers, including one of Indian-origin.

Using ultrasound and a blood test for high alpha fetoprotein (AFP) levels together improves detection of early-stage liver cancer significantly, said the study published in the journal Gastroenterology.

AFP is a plasma protein that is produced in abundance by the liver cells in the foetus. In adults, AFP levels are normally low, but liver cancer can cause AFP levels to rise.

“Liver cancer screening in patients with chronic liver disease has traditionally been performed using an abdominal ultrasound. While ultrasound is readily available and noninvasive, it misses many cancers when they are small,” said Amit Singal, associate professor at the University of Texas Southwestern Medical Centre.

Risk factors for liver cancer — also known as hepatocellular carcinoma (HCC) — include hepatitis C infection, chronic heavy alcohol consumption, and nonalcoholic fatty liver disease related to diabetes and obesity.

Symptoms can include upper abdominal pain or swelling, loss of weight or appetite, white chalky stools, and general fatigue, the researchers said.

“Our study found that adding the blood biomarker alpha fetoprotein increased detection of early-stage hepatocellular carcinoma from 45 per cent with ultrasound alone to 63 per cent using the two tests in combination,” Singal said.

Liver cancer screening guidelines for patients with cirrhosis vary, with some guidelines calling for just imaging and other guidelines calling for both imaging and AFP measurement.

“Our results support a change in clinical practice and the routine use of ultrasound and biomarkers together for liver cancer screening,” Singal said.

The results were based on a meta-analysis of 32 previous studies. Meta-analysis refers to a technique of combining the results of multiple scientific studies.

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New blood test may help early detection of 8 cancers https://odishatv.in/health/new-blood-test-may-help-early-detection-of-8-cancers-270483 Mon, 22 Jan 2018 01:08:18 +0000 http://odishatv.in/?p=270483

Sydney: A new blood test that can help in the early diagnoses of eight common cancers before they spread and risk patients’ chances of survival has been developed by Australian researchers. The new test would help early detection of cancers affecting the ovary, liver, stomach, pancreas, oesophagus, bowel, lung and breast, Xinhua quotes a statement […]

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Sydney: A new blood test that can help in the early diagnoses of eight common cancers before they spread and risk patients’ chances of survival has been developed by Australian researchers.

The new test would help early detection of cancers affecting the ovary, liver, stomach, pancreas, oesophagus, bowel, lung and breast, Xinhua quotes a statement from the Walter and Eliza Hall Institute of Medical Research in Australia.

The test “has the potential to be a one-stop, safe screening test for multiple tumour types that should have high community acceptance,” Jeanne Tie, Associate Professor at the institute was quoted as saying.

“For the first time, we have the promise of a screening test that will lead to earlier diagnosis and improved survival outcomes for many tumor types that are major contributors to cancer deaths in our community,” Tie added.

Cancer survival rates are directly linked to how advanced the disease is in a patient during diagnosis, which means that blood tests that can accurately detect the illness well before the symptoms are present is urgently needed.

There are still no effective screening tests for many major tumor types and available tests can each only screen for one cancer at a time, the report said.

The new blood test, reported in the journal Science, screens for key proteins and gene mutations that indicate the presence of the cancers.

It was able to detect tumours in patients in the early stages of the condition in about 70 per cent of the cases.

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New blood test can predict onset of Huntington’s disease https://odishatv.in/science/new-blood-test-can-predict-onset-of-huntingtons-disease-220606 Thu, 08 Jun 2017 11:22:50 +0000 http://odishatv.in/?p=220606

London: In a first, a blood test that can predict the onset and track progression of Huntington’s disease has been developed. The finding may help identify new treatments for the genetic brain disorder, which is fatal and currently incurable. Huntington’s disease is an inherited condition in which nerve cells in the brain break down over […]

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London: In a first, a blood test that can predict the onset and track progression of Huntington’s disease has been developed.

The finding may help identify new treatments for the genetic brain disorder, which is fatal and currently incurable.

Huntington’s disease is an inherited condition in which nerve cells in the brain break down over time.

The study showed that measuring the levels of neurofilament — a protein released from damaged brain cells — may help predict the onset of the disease as well as its progression.

“This is the first time a potential blood biomarker has been identified to track Huntington’s disease so strongly,” said Edward Wild from the University College London.

The results showed that the patients who were carriers of the genetic mutation of the disease had neurofilament concentrations that were 2.6 times that of the control participants.

Further, the level rose throughout the disease course from premanifest to stage 2 diseases, the researchers said.

“Neurofilament has the potential to serve as a speedometer in Huntington’s disease, since a single blood test reflects how quickly the brain is changing,” Wild added.

For the study, published in the journal Lancet Neurology, the team measured neurofilament levels in blood samples from 366 volunteers who were followed for three years.

In the group who had no symptoms at the start of the study, the level of neurofilament predicted subsequent disease onset, as volunteers with high neurofilament levels in the blood at the start were more likely to develop symptoms in the following three years.

Scientists are presently in the process of testing a new generation of so-called ‘gene silencing’ drugs that may put brakes on the disease.

“Measuring neurofilament levels could help us figure out whether those brakes are working,” Wild noted.

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blood test, Huntington's disease 2017-06-08 16:52:50 https://odishatv.in/wp-content/uploads/2017/06/Huntington.jpg
Angelina Jolie was drug-tested for ‘Lara Croft’ https://odishatv.in/entertainment/angelina-jolie-was-drug-tested-for-lara-croft-203843 Thu, 30 Mar 2017 10:40:54 +0000 http://odishatv.in/?p=203843

Los Angeles: Actress Angelina Jolie reportedly had to undergo drug tests to prove herself worthy for the title role in 2001 film “Lara Croft: Tomb Raider”. According to an upcoming biography of actress and film executive Sherry Lansing, who was the CEO of Paramount Pictures earlier, Jolie was asked to undergo a few drug tests […]

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Los Angeles: Actress Angelina Jolie reportedly had to undergo drug tests to prove herself worthy for the title role in 2001 film “Lara Croft: Tomb Raider”.

According to an upcoming biography of actress and film executive Sherry Lansing, who was the CEO of Paramount Pictures earlier, Jolie was asked to undergo a few drug tests for the role, reports hollywoodreporter.com.

According to Simon West, who directed “Lara Croft: Tomb Raider”, Jolie had “dark reputation” at that time, which included rumours that she dabbled in drugs.

“She definitely had some baggage and something of a dark reputation. Funnily enough, that was one of my selling points: This troubled and dangerous aspect in her reputation actually helped the character,” West said.

West later decided to meet up with Jolie on “Original Sin” filming set in Mexico.

The director recalled that at that moment, Jolie said, “Look, I want to do it, but I know what my reputation is, and I’ll do anything you want to prove that I’m worthy. I’ll be reliable, and I’ll turn up, and I’ll work hard. I don’t care if the studio wants to drug test me every day.”

Later, Jolie was obliged to undergo drug tests which involved urine tests and blood tests. She passed the tests and finally landed the role, which helped her obtain superstar status in film industry.

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Angelina Jolie, blood test, dark reputation, drug tested, Lara Croft: Tomb Raider, Original Sin, Paramount Pictures, Sherry Lansing 2017-03-30 16:10:54 https://odishatv.in/wp-content/uploads/2017/03/Angelina-Jolie-Tomb-Raider.jpg