Japan’s stem cell breakthrough helps paralysed patient walk again

In a landmark development for spinal cord injury research, Japanese scientists have announced early yet promising results from a pioneering clinical study using reprogrammed stem cells to treat people with severe spinal injuries. 

The findings, revealed in March 2025, show that one patient who had been paralyzed was able to stand and begin walking with support following the novel therapy. This milestone, experts say, could reshape approaches to paralysis treatment worldwide.

Research At Keio University

The clinical trial, led by researchers at Keio University in Tokyo, Japan, involved transplanting neural cells derived from induced pluripotent stem (iPS) cells into the injured spinal cords of four patients. iPS cells are adult cells reprogrammed into an embryonic-like state, giving them the potential to become many different cell types, including nerve cells.

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According to the study results, two out of the four participants showed measurable improvement in motor function following the treatment and rehabilitation. One individual, previously unable to move or feel below the injury site, improved to the point of standing and began relearning to walk with assistance. Another patient regained some movement in arms and legs, though not yet able to stand independently. The remaining two showed smaller gains.

Study In Early Stages

Spinal cord injuries, which disrupt the vital connection between the brain and body, have long been considered largely irreversible once the damage is complete. 

While the study remains in early stages and results are preliminary, scientists around the world have hailed the breakthrough as a hopeful sign that regenerative medicine can one day transform the prognosis for paralysis.