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There is no proposal under consideration to hand over the doctor, Shakeel Afridi, to the US since he is facing judicial proceedings and a three-stage appeal process is yet to be disposed of, Islam was quoted as saying in media reports.
The Inter Services Intelligence chief spoke to reporters on the margins of a military function late Friday night.
Afridi was arrested shortly after the killing of bin Laden on May 2 last year for running a vaccination campaign in Abbottabad to try and collect DNA samples of bin Laden or his kin. He was recently given a 33-year prison term by a tribal court for alleged links with militants. Afridi has appealed against the sentence.
US Embassy spokesperson Rian Harris too said the US was not considering a prisoner exchange involving Siddiqui and Afridi.
Speaking on the sidelines of an event hosted by the army chief to mark the Defence of Pakistan Day, Islam said no discussions had taken place with the US on swapping Afridi for Siddiqui.
Islam refused to respond to a question about the possible involvement of foreign elements in the insurgency in Balochistan province but said the rebels were benefiting from space provided to them by flawed governance.
Intelligence agencies are always in search of a "foe`s weaknesses and especially the space for action", he said.
